Deerskins and Duffels documents the trading relationship between the Creek Indians in what is now the southeastern United States and the Anglo-American peoples who settled there. The Creeks were the largest native group in the Southeast, and through their trade alliance with the British colonies they became the dominant native power in the area.

This book is the first to examine extensively the Creek side of the trade, especially the impact of commercial hunting on all aspects of Indian society. British trade is detailed here, as well: the major traders and trading companies, how goods were taken to the Indians, how the traders lived, and how trade was used as a diplomatic tool. The author also discusses trade in Indian slaves, a Creek-Anglo cooperation that resulted in the virtual destruction of the native peoples of Florida.